Verywell Brain's Content is for informational and educational reasons only. Our Web-site isn't meant to become a substitute for Specialist professional medical information, prognosis, or treatment. Metabolism Alprazolam is thoroughly metabolized in human beings, primarily by cytochrome P450 3A4 (CYP3A4), to 2 important active metabolites inside the plasma: 4-hydroxyalprazolam and waiting for link from RSS